10 Comments
  1. Reply
    walaa Mohammed

    NEC affects multiple organs and its pathophysiology is multifactorial. Intraluminal bacteria disrupt and invade the intestinal epithelium at the tips of intestinal villi. Endotoxin binds to TLR4 receptor on the intestinal epithelial cells, activating pathogen associated molecular pattern receptors, which facilitate the breakdown of the gut barrier to translate leading to tissue injury.

  2. Reply
    Soheir Ibrahim Mohamed

    Actually Necrotizing enterocolitis (NEC) is the most common gastrointestinal (GI) medical/surgical emergency occurring in neonates. An acute inflammatory disease with a multifactorial and controversial etiology.

  3. Reply
    Lamiaa Rehan

    Prevention includes the use of breast milk and probiotics. A 2012 policy by the American Academy of Pediatrics recommended feeding preterm infants human milk, finding “significant short- and long-term beneficial effects,” including reducing the rate of NEC by a factor of two or more.
    Small amounts of oral feeds of human milk starting as soon as possible, while the infant is being primarily fed intravenously, primes the immature gut to mature and become ready to receive greater intake by mouth.[11] Human milk from a milk bank or donor can be used if mother’s milk is unavailable. The gut mucosal cells do not get enough nourishment from arterial blood supply to stay healthy, especially in very premature infants, where the blood supply is limited due to immature development of the capillaries, so nutrients from the lumen of the gut are needed.
    Towards understanding intervention with human milk, experts have noted cow and human milk differ in their immunoglobular and glycan compositions.Due to their relative ease of production, human milk oligosaccharides (HMO) are a subject of particular interest in supplementation and intervention.

  4. Reply
    Asmaa Abd Wakeel

    NEc is primaary disease process of GIT of Peter neonate neonate result in bacterial invasion of bowel wall despite advance in care it remains one of the leading cause of morbidity and mortality in this population

  5. Reply
    Eman Almorsy

    It is very important subject,thank you for great effort
    NEC is the most frustrating of condition with little to predict which babies will be hit by the disease (we lack biomarkers ,prediction and prevention strategies) and we do not have a cure.
    It is very interesting to find organization for NEC including clinician,researchers,and patient-families to express the need for the progress.

  6. Reply
    Karima Bahgat

    Necrotizing enterocolitis is among the most common and devastating diseases occurred in premature infants.Prematurity remains the most consistent risk factor, although term babies can develop NEC with a much lower incidence. the incidence increases with decreasing gestational age.signs and symptoms are quite variable, ranging from feeding intolerance to evidence of a fulminant intra-abdominal catastrophe with peritonitis, sepsis, shock, and death.

  7. Reply
    Karima Bahgat

    It is evident that human milk feeding can reduce the incidence of NEC. probiotic supplementation can significantly reduce the incidence of NEC in premature infants, but there are still some concerns regarding the safety, optimal dosage, and treatment duration of probiotic preparations. Antibiotic prophylaxis does not reduce the incidence of NEC. standardized feeding protocols are strongly recommended.

  8. Reply
    Amani

    NEC affects newborns of all gestational ages although it is more frequent in preterm babies .Risk factors include formula feeding versus breast milk, rapid advance of feeding volumes, chorioamnionitis, polycythemia with hyperviscosity, cyanotic heart disease and/or a precedent hypoxic-ischemic event or an illicit maternal drug history (especially cocaine) that leads to mesenteric ischemia.

  9. Reply
    Amani

    Early introduction of breast milk with a gradual standardized advance is the best current feeding practice for prevention of NEC in the preterm infant and likely has the greatest impact on NEC associated with delayed feeding.

  10. Reply
    Amani

    Early in the disease process, neonates have signs of feeding intolerance with vomiting, increased gastric aspirates, bile-tinged (green) gastric aspirates,oligurea, or decreased bowel sounds with abdominal distention and tenderness

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