Printing Materials

Printing Materials

Bruchure for the ENSTN

Anticonvulsant Drugs  

KLAUS & FANAROFF’S CARE OF THE HIGH-RISK NEONAT, 2013; Drug Dosing Table, McClary J/ Anticonvulsants

Medication (Trade Name)

Route of Administration

Dosing Important Adverse Events

 

Diazepam

IV

 

Initial loading dose:  0.1 mg/kg

Give IV dose over 3-5 Min

Repeat dose prn based on response

Respiratory depression,

hypotension

 

Levetiracetam

IV, PO

Give IV dose over 15 min

10-60 mg/kg/day divided every 12-24 hr

Sedation, irritability
Lorazepam

(Ativan)

PO/IV/IM

PO/IV/IM: 0.05-0.01 mg/kg repeated

based on clinical response

Slow push

Hypotension, respiratory depression, rhythmic myoclonic jerking, phlebitis
Midazolam

(Versed)

PO/IV/IM/IN/SL

 

IV push/IM: 0.05-0.15 mg/kg q2-4h prn

Continuous IV infusion: 0.01-0.06 mg/kg/hr, titrated as needed

IN/SL: 0.2 mg/kg

PO: 0.25 mg/kg

Slow push over at least 5 min

Hypotension, respiratory depression,

myoclonus

Phenobarbital

(Luminal)

PO/IV/IM

 

Loading dose: 20 mg/kg IV; repeat 5-10 mg/kg prn to total 40 mg/kg

Maintenance dose: 3-5 mg/kg q24h

IV, IM, or PO

Give IV dose over 10-15 min

Extravasation, respiratory depression, sedation, elevated liver enzymes
Phenytoin

(Dilantin)

PO/IV

 

Loading dose: 15-20 mg/kg IV

Maintenance dose: 4-8 mg/kg IV or PO q24h

Give IV dose over 30 min

Max infusion rate of 0.5 mg/kg/min

Bradycardia, arrhythmia, and hypotension during infusion; extravasation; rickets; nystagmus;

gingivitis