What this paper adds
1 We report the result of a systematic review to assess the efﬁ–
cacy and safety of octreotide in the treatment of congenital and
acquired chylothorax in newborns.
2 Octreotide is a relatively effective and safe treatment option in
neonates with chylothorax, especially for the congenital forms.
3 This systematic review suggests that octreotide therapy should
be considered an adjunctive treatment in term and preterm neo-
nates affected by congenital and acquired chylothorax